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Unifiram CAS 272786-64-8 AMPA Receptor Agonist Cognition Enhancer
Brief Introduction
Brief Introduction
Unifiram is a highly potent AMPAkine-like nootropic with antiamnesic and cognition-enhancing effects in animal studies at up to three orders of magnitude higher potency than piracetam.
Unifiram, also known as DM-232, is a research compound widely discussed in cognitive and neurochemical studies. It has attracted attention in laboratory research related to memory, learning, and neurotransmitter activity. This product is typically supplied as a high-purity research material for laboratory and analytical purposes. It is commonly referenced in nootropic compound research and related chemical studies. For research use only.
Unifiram, also known as DM-232, is a research compound widely discussed in cognitive and neurochemical studies. It has attracted attention in laboratory research related to memory, learning, and neurotransmitter activity. This product is typically supplied as a high-purity research material for laboratory and analytical purposes. It is commonly referenced in nootropic compound research and related chemical studies. For research use only.
Unifiram (development code: DM232) is a pyrrolopyrazine-class synthetic compound structurally related to Sunifiram (DM-235). As a potent cognition enhancer, Unifiram exhibits four orders of magnitude (10,000-fold) higher potency than the classic nootropic piracetam in preclinical studies . Through positive modulation of AMPA receptor-mediated neurotransmission, it holds significant research potential in amnesia prevention and neurodegenerative disorder studies .
Key Scientific Value & Findings
Ultra-High Potency - 10,000-fold Stronger than Piracetam: Unifiram demonstrates four orders of magnitude (10,000-fold) higher potency than piracetam in anti-amnesic potential. In rat models, Unifiram at 0.1 mg/kg produces cognitive-enhancing effects comparable to 30 mg/kg piracetam.
AMPA Receptor-Mediated Synaptic Enhancement: Unifiram induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the rat hippocampal CA1 region, with an EC50 value as low as 27 nM . This effect indicates that Unifiram enhances synaptic plasticity through AMPA receptor potentiation, a cellular basis for learning and memory formation.
Acetylcholine Release Promotion: Unifiram significantly increases acetylcholine (ACh) release in the rat cerebral cortex . Acetylcholine is a key neurotransmitter closely associated with learning and memory, further supporting its cognition-enhancing mechanism.
Broad Anti-Amnesic Effects: Unifiram demonstrates significant protective effects in various amnesia models:
Scopolamine-Induced Amnesia: Unifiram (0.1 mg/kg i.p.) prevents amnesia induced by scopolamine in the rat Morris water maze test
Social Learning Memory Enhancement: In the rat social learning test, Unifiram (0.1 mg/kg i.p.) reduces active exploration time of familiar partners, indicating enhanced social recognition memory
Pentobarbital-Induced Hypnosis: Similar to piracetam, Unifiram reduces pentobarbital-induced hypnosis time
Favorable Safety Profile: At the highest effective doses, Unifiram neither affects motor coordination (rotarod test) nor alters spontaneous behavior (Animex test), suggesting a favorable safety profile
Our Supply & Service Advantages
Our Supply & Service Advantages
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