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Unifiram CAS 272786-64-8 - AMPA Receptor Agonist Cognition Enhancer from China Suppliers and Factory
Brief Introduction
Unifiram is a highly potent AMPAkine-like nootropic with antiamnesic and cognition-enhancing effects in animal studies at up to three orders of magnitude higher potency than piracetam.
Unifiram, also known as DM-232, is a research compound widely discussed in cognitive and neurochemical studies. It has attracted attention in laboratory research related to memory, learning, and neurotransmitter activity. This product is typically supplied as a high-purity research material for laboratory and analytical purposes. It is commonly referenced in nootropic compound research and related chemical studies. For research use only.
Unifiram (DM232) is a pyrrolopyrazine-class synthetic compound structurally related to Sunifiram (DM-235). As a potent cognition enhancer, Unifiram exhibits four orders of magnitude (10,000-fold) higher potency than the classic nootropic piracetam in preclinical studies. Through positive modulation of AMPA receptor-mediated neurotransmission, it holds significant research potential in amnesia prevention and neurodegenerative disorder studies.
Key Scientific Value & Findings
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Ultra-High Potency — 10,000-fold Stronger than Piracetam
Unifiram demonstrates four orders of magnitude (10,000-fold) higher potency than piracetam in anti-amnesic potential. In rat models, Unifiram at 0.1 mg/kg produces cognitive-enhancing effects comparable to 30 mg/kg piracetam.
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AMPA Receptor-Mediated Synaptic Enhancement
Unifiram induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the rat hippocampal CA1 region, with an EC50 value as low as 27 nM. This effect enhances synaptic plasticity through AMPA receptor potentiation — a cellular basis for learning and memory formation.
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Acetylcholine Release Promotion
Unifiram significantly increases acetylcholine (ACh) release in the rat cerebral cortex. Acetylcholine is a key neurotransmitter closely associated with learning and memory, further supporting its cognition-enhancing mechanism.
Broad Anti-Amnesic Effects
Unifiram demonstrates significant protective effects in various amnesia models:
- Scopolamine-Induced Amnesia: Unifiram (0.1 mg/kg i.p.) prevents amnesia induced by scopolamine in the rat Morris water maze test.
- Social Learning Memory Enhancement: In the rat social learning test, Unifiram (0.1 mg/kg i.p.) reduces active exploration time of familiar partners, indicating enhanced social recognition memory.
- Pentobarbital-Induced Hypnosis: Similar to piracetam, Unifiram reduces pentobarbital-induced hypnosis time.
Favorable Safety Profile: At the highest effective doses, Unifiram neither affects motor coordination (rotarod test) nor alters spontaneous behavior (Animex test), suggesting a favorable safety profile.
Our Supply & Service Advantages
Frequently Asked Questions
What is Unifiram (DM-232) and how does it differ from piracetam?
Unifiram (DM-232) is a pyrrolopyrazine-class synthetic nootropic compound that exhibits approximately 10,000-fold (four orders of magnitude) higher potency than piracetam in preclinical anti-amnesic studies. Unlike piracetam, Unifiram primarily acts through positive modulation of AMPA receptor-mediated neurotransmission and promotes acetylcholine release in the cerebral cortex.
What is the primary mechanism of action of Unifiram?
Unifiram works mainly by positively modulating AMPA receptors, leading to a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the hippocampal CA1 region (EC50 ≈ 27 nM). It also promotes acetylcholine (ACh) release in the cerebral cortex, both of which are closely linked to learning and memory processes.
What amnesia models has Unifiram been tested in?
Unifiram has demonstrated significant protective effects in multiple preclinical amnesia models, including scopolamine-induced amnesia (Morris water maze test), pentobarbital-induced hypnosis models, and social learning memory tests in rats. In each model, Unifiram at 0.1 mg/kg i.p. showed meaningful cognitive-enhancing effects.
Is Unifiram safe at effective doses based on preclinical data?
Based on available preclinical research, Unifiram at its highest effective doses did not affect motor coordination (as assessed by the rotarod test) nor alter spontaneous behavior (Animex test), suggesting a favorable preclinical safety profile. However, this product is strictly for laboratory and research use only and is not intended for human consumption.
How is Unifiram related to Sunifiram?
Unifiram (DM-232) and Sunifiram (DM-235) are both pyrrolopyrazine-class synthetic compounds and are structurally related. They share similar AMPAkine-like properties and cognition-enhancing profiles in preclinical studies, though they are distinct chemical entities with potentially different potency and activity profiles.
What is the intended use of Unifiram supplied by your company?
Unifiram is supplied exclusively as a high-purity research material intended for laboratory and analytical purposes. It is commonly referenced in nootropic compound research, neurochemical studies, and related chemical analysis. This product is strictly for research use only and is not approved for human or veterinary use.