Product Name: SNAP-8 / Acetyl Octapeptide-3
CAS No.: 868844-74-0
Appearance: White to off-white powder
Purity: ≥98% (HPLC)
Grade: Cosmetic Grade
Testing Report: Certificate of Analysis (COA) available, including purity testing, heavy metals testing, and microbiological testing.
Origin: China
Storage: Store in a cool, dry place away from light and moisture.
Shelf Life: 24 months under recommended storage conditions.
Standard Packaging: 1g / 10g / 100g / 1kg
Bulk Supply: Large-volume supply available for cosmetic manufacturers and distributors.
Customized Packaging: Custom packaging and OEM labeling available upon request.
SNAP-8 (Acetyl Octapeptide-3) is a synthetic peptide that mimics the N-terminal structure of the SNAP-25 protein, developed by the internationally renowned cosmetic ingredient supplier Lipotec (now part of Lubrizol) . It is an elongation of the popular Acetyl Hexapeptide-3 (ARGIRELINE®) by two amino acid residues, designed to achieve better anti-wrinkle effects . SNAP-8 competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation, reducing neurotransmitter release, and achieving muscle relaxation and expression line fading .
Key Scientific Value & Findings
Unique Mechanism of Action - Botox-like but Non-Paralytic: SNAP-8 has a similar target to Botox (both target SNAP-25 protein), but with different mechanisms of action :
Botox: Cleaves the SNAP-25 protein, causing neuromuscular junction paralysis - potent but irreversible
SNAP-8: As a SNAP-25 mimetic peptide, it competitively occupies positions in the SNARE complex, modulating complex formation and relaxing muscles rather than paralyzing them, thus offering higher safety
Superior to Acetyl Hexapeptide-3: SNAP-8 was designed by adding two amino acids to Acetyl Hexapeptide-3 to achieve better wrinkle improvement effects . Studies indicate that SNAP-8 is more effective than Acetyl Hexapeptide-3 .
SNARE Complex Modulation: SNAP-8 is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation . The SNARE complex plays a key role in neurotransmitter release; modulating its formation regulates the transmission of muscle contraction signals.
High Safety Profile: Compared to Botox, SNAP-8 offers higher safety . Botox cleaves the SNAP-25 protein, while SNAP-8 merely competitively occupies positions without destroying protein structure, resulting in mild and reversible effects.
