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SLU-PP-915 CAS 2285432-92-8 ERR Agonist Metabolic Research
Brief Introduction
Brief Introduction
Novel mitochondrial metabolism modulator
Designed for advanced obesity & metabolic disorder research
Potential thermogenic pathway activator
High purity ≥98% (HPLC)
Stable powder form, scalable synthesis
Suitable for in vitro & preclinical studies
Reliable bulk supply from China manufacturer
Custom synthesis & COA available
SLU-PP-915 (development code: 915) is a pan-estrogen-related receptor (pan-ERR) agonist developed by Saint Louis University and other institutions through a structure-based drug design approach . It is a next-generation compound structurally optimized from the well-studied SLU-PP-332, with the key improvement being the introduction of a boronic acid moiety that confers the critical advantage of oral bioavailability . SLU-PP-915 simultaneously activates all three ERR isoforms (α, β, and γ), regulating core metabolic processes such as mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation, and is regarded as a promising "exercise mimetic" .
Key Scientific Value & Findings
Oral Bioavailability - A Key Breakthrough: The first-generation compound SLU-PP-332, while effective, lacked oral bioavailability, limiting its application in chronic dosing studies . SLU-PP-915, through structural optimization (incorporating a boronic acid group), exhibits significantly improved metabolic stability, making it the first orally active, potent pan-ERR agonist .
Enhanced Aerobic Exercise Capacity: Studies show that when administered intraperitoneally, SLU-PP-915 enhances aerobic exercise performance (distance and duration) in mice to an extent similar to SLU-PP-332. Importantly, this efficacy is maintained when administered orally after adjusting for systemic exposure, demonstrating excellent oral activity . This highlights its significant potential as an oral "exercise mimetic."
Improved Cardiac Function in Heart Failure: In a mouse model of pressure overload-induced heart failure, treatment with SLU-PP-915 (and SLU-PP-332) significantly improved ejection fraction, ameliorated fibrosis, and increased survival without affecting cardiac hypertrophy . The mechanism involves transcriptional activation of metabolic gene networks involved in fatty acid metabolism and mitochondrial function, leading to substantial normalization of metabolic profiles for fatty acids/lipids and TCA/oxidative phosphorylation metabolites in the heart .
Activation of ERR Target Genes: SLU-PP-915 potently upregulates the expression of ERR target genes such as DNA damage-inducible transcript 4 (Ddit4) , PGC-1α, lactate dehydrogenase A (LDHA), and pyruvate dehydrogenase kinase 4 (PDK4), which play central roles in energy metabolism of skeletal muscle and heart .
Synergy with Exercise Training: Notably, SLU-PP-915 synergizes with actual exercise training to further enhance the expression of Ddit4 and mitochondrial genes . This provides a basis for studying the potential applications of combining pharmacological intervention with exercise.
ERRγ as the Primary Mediator: In vitro and in vivo genetic dependency experiments have demonstrated that ERRγ is the primary mediator of ERR agonist-induced transcriptional regulation and cardioprotection .
Our Supply & Service Advantages
Our Supply & Service Advantages
we are committed to providing global customers with comprehensive support ranging from products to services:
Stable Supply, Consistent Quality: Leveraging robust Chinese manufacturing resources, we ensure stable delivery of bulk orders with consistent quality across all batches.
Strong Price Competitiveness: Our factory-direct supply system eliminates intermediary costs, offering you highly competitive prices in the market.
Quality Assurance, Fully Traceable: We implement strict quality control systems and provide complete documentation, including Certificates of Analysis (CoA), heavy metal and microbiological test reports.
Flexible Packaging, Custom Services: We offer diverse packaging options (such as 1kg aluminum foil bags and 25kg fiber drums) and can meet customization needs including OEM and private label services.
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We provide COA (Certificate of Analysis) for each batch. Third-party testing is welcome