Romifidine Hydrochloride CAS 65896-14-2 | Pharmaceutical Chemical
Romifidine hydrochloride (CAS No. 65896-14-2) is a highly potent and selective α2-adrenoceptor agonist used in veterinary medicine as a sedative and analgesic.
**Key Characteristics and Mechanism of Action**
**Basic Information:** Its molecular formula is C₉H₁₀BrClFN₃, and its molecular weight is 294.55. It typically appears as a white solid.
**Mechanism of Action:** As an α2-adrenoceptor agonist, it induces sedation and analgesia by stimulating α2-receptors in the central nervous system. Upon initial administration, it acts on peripheral vascular smooth muscle, causing a transient rise in blood pressure; this is subsequently followed by a hypotensive effect resulting from a decrease in central sympathetic tone.
**Veterinary Applications**
Romifidine hydrochloride is intended exclusively for use in animals and has no application in human medicine. Its primary uses are as follows:
**Target Species:**
**Horses:** This is its primary area of application. The FDA-approved product, marketed as Sedivet, is used for sedation in horses. In regions such as the UK, it is also approved for use in dogs and cats.
**Core Uses:**
**Sedation and Restraint:** Facilitates clinical examinations, radiography, minor surgical procedures, and routine handling.
**Pre-anesthetic Medication:** Serves as a pre-anesthetic agent; it is often used in combination with drugs such as ketamine or thiopental sodium to enhance anesthetic efficacy and reduce the required dosage of the primary anesthetic agent.
**Deep Sedation/Analgesia:** Can be combined with opioid analgesics (such as buprenorphine) to achieve more profound and prolonged sedation and analgesia.
The primary clinical application of Romifidine Hydrochloride is as a sedative and pre-anesthetic agent in veterinary medicine, particularly for large animals such as horses. Its key applications and usage protocols are summarized below:
Horses: Core Applications and Detailed Protocols
This is the most established and widely used area for Romifidine Hydrochloride. Taking the trade name *Sedivet* as an example, its approved indications include:
Sedation for clinical procedures: Used to facilitate procedures, clinical examinations, minor surgeries, and handling.
Pre-anesthetic medication: Used as a pre-treatment agent prior to anesthesia induction; it can be combined with drugs such as ketamine or thiopental sodium.
Deep sedation/analgesia: When stronger analgesic effects are required, it can be combined with opioids such as buprenorphine or butorphanol.
Dogs and Cats: Small Animal Clinical Applications
In addition to horses, Romifidine Hydrochloride is also used for sedation in dogs and cats. Taking the trade name *Romidys* as an example, its applications include:
Indications: Used for sedation and restraint in dogs and cats to facilitate clinical examinations and minor surgical procedures; it can also serve as a pre-induction agent for general anesthesia.
Routes of administration: In dogs, it can be administered via intramuscular, intravenous, or subcutaneous injection; in cats, via intravenous or intramuscular injection.
Deep sedation: In dogs, combination with opioid analgesics can achieve deep sedation/analgesia; in cats, combination with ketamine can achieve a depth of anesthesia suitable for surgery.
Other Large Animals
Records indicate that Romifidine Hydrochloride can also be used for sedation in animals such as elephants.