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Phenylpiracetam CAS 77472-71-0 Anti-fatigue Nootropic Agent
Brief Introduction
Brief Introduction
Phenylpiracetam (development code: Carphedon; trade names: Phenotropil, Fonturacetam) is a phenyl analog of the classic nootropic Piracetam, modified by introducing a phenyl group at the 4th position of the pyrrolidinone ring. This structural modification significantly enhances its lipophilicity and blood-brain barrier penetration, resulting in several-fold higher potency compared to Piracetam. Phenylpiracetam not only exhibits significant cognition-enhancing effects but also demonstrates anti-fatigue, antidepressant, anticonvulsant, and most recently discovered metabolic regulatory activities, making it an important tool compound in neuroscience and metabolic disease research .
Key Scientific Value & Findings
Enhanced Nootropic Activity: As a member of subgroup 1 of racetam drugs, Phenylpiracetam exhibits higher potency than Piracetam and a broader range of indications. It is used in research on cognitive disorders, cerebrovascular diseases, cognitive function recovery after traumatic brain injury, as well as neurological conditions such as myoclonus epilepsy and tardive dyskinesia .
Metabolic Regulation and Anti-Obesity Effects: Latest research published in 2024 revealed novel molecular mechanisms of Phenylpiracetam (Fonturacetam) in obesity treatment. Chemoreactomic analysis indicates that Phenylpiracetam exerts its therapeutic effects through multi-level regulation of targets controlling fat and carbohydrate metabolism:
Activated receptors: β3-adrenoceptors, adenosine receptors, glucagon-like peptide receptors, sphingosine phosphate receptors, peroxisome proliferator-activated receptors (PPARG)
Inhibited receptors: cannabinoid receptors, opioid receptors, histamine receptors, glutamate receptors, nociceptin receptors, neuropeptide Y receptors, orexin receptors
These actions contribute to reducing excess appetite, preventing excessive body weight accumulation, and exhibiting lipotropic effects .
Enantiomer-Specific Activity: The pharmacological activity of Phenylpiracetam is closely related to its stereochemistry. (4R)-phenylpiracetam ((R)-enantiomer) is the main active component responsible for cognition-enhancing effects. Studies confirm the pharmacological advantages of single enantiomers, justifying the choice of the most effective stereoisomer and the necessity for drug substance purification from the less active one(s) .
Brain Imaging Agent Development: Recent studies explored the potential application of radioiodinated Phenylpiracetam ([¹³¹I]-PHPI) as a novel brain imaging agent. Biodistribution studies indicate that the [¹³¹I]-PHPI tracer highly concentrates in the target organ (brain), showing potential as a highly selective radiotracer for brain tumor imaging compared to commercially available tracers [⁹⁹ᵐTc]ECD and [⁹⁹ᵐTc]HMPAO
Our Supply & Service Advantages
Our Supply & Service Advantages
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