O-304 CAS 1261289-04-6 | AMPK Activator | Research Compound
O-304 (CAS 1261289-04-6) is a first-in-class, orally available pan-AMPK activator. It increases AMPK activity by suppressing the dephosphorylation of pAMPK. This compound shows great potential for treating type 2 diabetes and associated cardiovascular complications and has entered Phase IIa clinical trials
Type 2 Diabetes Research: In Phase IIa clinical trials, O-304 reduced fasting plasma glucose levels and HOMA-IR in T2D patients
Cardiovascular Complications Research: Reduces systemic blood pressure and increases microvascular perfusion
Kidney Protection Research: Reversibly reduces eGFR in type 2 diabetes patients
PCSK9 Modulation Research: Reduces secreted PCSK9 levels in human liver cells and lowers total cholesterol in obese rats
Metabolic Disease Research: Used in studies on obesity, insulin resistance, and related conditions