Noopept GVS-111 Nootropic Peptide 157115-85-0 - High Purity Powder from China Suppliers & Factory
Brief Introduction
Ultra-High Potency
1000-fold Stronger than Piracetam: Experimental studies show that Noopept exceeds piracetam by 1000 times in effective dose level. In contrast to piracetam facilitating only the early stages of the memory process, Noopept positively influences the memory consolidation and retrieval steps as well. Additionally, Noopept produces an additional selective anxiolytic action.
Unique Neuroprotective Mechanism
Noopept demonstrates pronounced neuroprotective effects confirmed both in vivo (in various forms of brain ischemia) and in vitro (on various neuronal models). Its action is based on:
- Antioxidant effect
- Anti-inflammatory action
- Ability to inhibit neurotoxicity of excess calcium and glutamate
- Improvement of blood rheology
α7 Nicotinic Acetylcholine Receptor Modulation
A 2022 study found that Noopept (5 µM) increases action potential firing frequency recorded from GABAergic interneurons in the stratum radiatum of hippocampal CA1 region. This effect was almost completely abolished by α7 nAChR-selective antagonists (α-bungarotoxin and methyllycaconitine), indicating that α7 nAChRs are an important site of action of Noopept.
HIF-1 Signaling Pathway Activation
Research indicates that Noopept is a moderate activator of the HIF-1 signaling pathway, acting through HIF-1 stabilization, likely by inducing HIF-1α transcription and translation, resulting in increased HIF-dependent gene expression. This mechanism may contribute to its neurotropic activity.
Alzheimer's Disease Research Potential
- In an Alzheimer's disease model induced by β-amyloid (25-35) injection into Meynert basal nuclei, Noopept (0.5 mg/kg, preventive intraperitoneal injections) completely prevented mnestic disorders.
- Even when treatment was started 15 days after injury (when neurodegenerative changes were still acutely pronounced), Noopept exhibited a significant normalizing effect.
- Mechanisms include: choline-positive effect, multicomponent neuroprotective effect, stimulation of antibody production to β-amyloid.
Oral Bioavailability Advantage
It was established for the first time that the activity of Noopept is retained both upon parenteral introduction and upon peroral administration, which is a principal advantage of this proline-containing dipeptide over other, more complex peptides. This property provided a basis for the development of oral formulations.
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Frequently Asked Questions
How does Noopept compare to Piracetam in terms of potency?
Noopept is over 500 to 1000 times more potent than Piracetam. Unlike piracetam, which only facilitates the early stages of memory, Noopept positively influences memory consolidation and retrieval steps, while also producing an additional selective anxiolytic (anti-anxiety) effect.
What are the primary neuroprotective mechanisms of Noopept?
Noopept's neuroprotective action is based on its antioxidant effect, anti-inflammatory action, ability to inhibit the neurotoxicity of excess calcium and glutamate, and the improvement of blood rheology.
What is the significance of the α7 Nicotinic Acetylcholine Receptor in Noopept's function?
Research indicates that Noopept increases action potential firing frequency in GABAergic interneurons of the hippocampal CA1 region. This effect is mediated by α7 nicotinic acetylcholine receptors (nAChRs), making them an important site of action for Noopept.
How does Noopept support research in Alzheimer's disease?
In Alzheimer's models, Noopept has been shown to prevent mnestic (memory) disorders, even when administered 15 days after injury when neurodegenerative changes are pronounced. Its mechanisms include a choline-positive effect, multicomponent neuroprotection, and the stimulation of antibody production to β-amyloid.
What is the bioavailability advantage of Noopept?
Unlike other complex peptides, Noopept retains its biological activity when administered both parenterally and perorally (orally). This oral bioavailability is a major advantage of this proline-containing dipeptide, allowing for the development of oral formulations.