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China SNAP-8 Acetyl Octapeptide-3 | Premium Anti-Aging Cosmetic Ingredient from Trusted Suppliers and Factory
Product Specifications & Packaging Information
Product Name
SNAP-8 / Acetyl Octapeptide-3
CAS No.
868844-74-0
Appearance
White to off-white powder
Purity
≥98% (HPLC)
Grade
Cosmetic Grade
Origin
China
Shelf Life
24 months under recommended storage conditions
Storage
Store in a cool, dry place away from light and moisture
📋 Testing Report: Certificate of Analysis (COA) available, including purity testing, heavy metals testing, and microbiological testing.
Standard Packaging
1g
10g
100g
1kg
🏭 Bulk Supply: Large-volume supply available for cosmetic manufacturers and distributors.
🎨 Customized Packaging: Custom packaging and OEM labeling available upon request.
SNAP-8 (Acetyl Octapeptide-3) is a synthetic peptide that mimics the N-terminal structure of the SNAP-25 protein, developed by the internationally renowned cosmetic ingredient supplier Lipotec (now part of Lubrizol). It is an elongation of the popular Acetyl Hexapeptide-3 (ARGIRELINE®) by two amino acid residues, designed to achieve better anti-wrinkle effects. SNAP-8 competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation, reducing neurotransmitter release, and achieving muscle relaxation and expression line fading.
Key Scientific Value & Findings
- Unique Mechanism of Action — Botox-like but Non-Paralytic SNAP-8 has a similar target to Botox (both target SNAP-25 protein), but with different mechanisms of action.
- Superior to Acetyl Hexapeptide-3 SNAP-8 was designed by adding two amino acids to Acetyl Hexapeptide-3 to achieve better wrinkle improvement effects. Studies indicate that SNAP-8 is more effective than Acetyl Hexapeptide-3.
- SNARE Complex Modulation SNAP-8 is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation. The SNARE complex plays a key role in neurotransmitter release; modulating its formation regulates the transmission of muscle contraction signals.
Botox vs. SNAP-8: Mechanism Comparison
Botox
Cleaves the SNAP-25 protein, causing neuromuscular junction paralysis — potent but irreversible.
SNAP-8
As a SNAP-25 mimetic peptide, it competitively occupies positions in the SNARE complex, modulating complex formation and relaxing muscles rather than paralyzing them — offering higher safety.
🛡️
High Safety Profile: Compared to Botox, SNAP-8 offers higher safety. Botox cleaves the SNAP-25 protein, while SNAP-8 merely competitively occupies positions without destroying protein structure, resulting in mild and reversible effects.
Key Benefits & Applications
Frequently Asked Questions
What is SNAP-8 (Acetyl Octapeptide-3) and how does it work?
SNAP-8, also known as Acetyl Octapeptide-3, is a synthetic peptide that mimics the N-terminal structure of the SNAP-25 protein. It works by competitively occupying positions in the SNARE complex, thereby modulating its formation, reducing neurotransmitter release, relaxing facial muscles, and reducing the appearance of expression lines and wrinkles.
How is SNAP-8 different from Botox?
Both SNAP-8 and Botox target the SNAP-25 protein, but their mechanisms differ significantly. Botox cleaves the SNAP-25 protein, causing irreversible neuromuscular paralysis. SNAP-8, by contrast, competitively occupies positions in the SNARE complex without destroying the protein structure, resulting in mild, reversible muscle relaxation — making it a safer topical alternative.
Is SNAP-8 more effective than Acetyl Hexapeptide-3 (ARGIRELINE®)?
Yes. SNAP-8 is an elongation of Acetyl Hexapeptide-3 with two additional amino acid residues. This structural enhancement is designed to improve its affinity for the SNARE complex. Studies indicate that SNAP-8 delivers more effective wrinkle reduction compared to Acetyl Hexapeptide-3.
What is the recommended purity and grade of your SNAP-8 product?
Our SNAP-8 is Cosmetic Grade with a purity of ≥98% as verified by HPLC analysis. Each batch comes with a Certificate of Analysis (COA) that includes results for purity testing, heavy metals testing, and microbiological testing, ensuring consistent quality for cosmetic formulation use.
What packaging options are available for SNAP-8?
Standard packaging options include 1g, 10g, 100g, and 1kg. We also support bulk supply for cosmetic manufacturers and distributors, as well as customized packaging and OEM labeling upon request. Please contact us for specific requirements.
How should SNAP-8 be stored, and what is its shelf life?
SNAP-8 should be stored in a cool, dry place away from direct light and moisture. Under these recommended storage conditions, the shelf life is 24 months. Proper storage is essential to maintain peptide stability and ensure consistent performance in cosmetic formulations.