Alpha-GPC 28319-77-9 50% Powder 99% Liquid Food Grade Bulk

All products of our company are for export only and are intended for laboratory and research use in legal and non-patented regions. They are strictly prohibited for personal or animal use. Those who illegally abuse them shall bear full responsibility for the consequences arising therefrom.All products of our company are for export only and are intended for laboratory and research use in legal and non-patented regions. They are strictly prohibited for personal or animal use. Those who illegally abuse them shall bear full responsibility for the consequences arising therefrom.

Alpha-GPC (L-alpha-glycerylphosphorylcholine, also known as choline alfoscerate) is a natural choline compound found in the brain and in milk . It is a biosynthetic precursor of acetylcholine and rapidly delivers choline to the brain across the blood-brain barrier . As a parasympathomimetic acetylcholine precursor, Alpha-GPC demonstrates significant research value in studies of Alzheimer's disease, dementia, post-seizure cognitive impairment, and stress-induced cognitive decline .

Key Scientific Value & Findings

Acetylcholine Synthesis Precursor: Alpha-GPC is a common choline compound and acetylcholine precursor in the brain, which has been shown to be effective in the treatment of Alzheimer's disease and dementia . It enhances cholinergic neurotransmission by directly elevating acetylcholine levels in the hippocampus and has been shown to increase learning and memory in stroke patients .

Blood-Brain Barrier Penetration: Alpha-GPC rapidly delivers choline to the brain across the blood-brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter . This property makes it an important tool for studying the central cholinergic system.

Improvement of Post-Seizure Cognitive Impairment: In a rat model of pilocarpine-induced seizure, delayed administration of Alpha-GPC (250 mg/kg, i.m., once daily for 3 weeks, starting 3 weeks after seizure) significantly improved cognitive function through reduced neuronal death, reduced BBB disruption, and increased hippocampal neurogenesis . Interestingly, early administration (starting immediately after seizure) showed no neuroprotective effects .

Protection Against Stress-Induced Cognitive Impairment: In a rat model of dual stress (noise plus restraint), Alpha-GPC (400 mg/kg, oral, for 7 days) demonstrated significant cognitive protection. Stress animals treated with Alpha-GPC showed better memory function in the novel object recognition test, with mechanisms involving increased hippocampal ChAT and BDNF expression, enhanced neuronal differentiation, and inhibition of neuroinflammation .

Cholinergic Neurotransmission Modulation: In a mouse model of scopolamine-induced cognitive impairment, Alpha-GPC derived from soybean lecithin (SHCog™, 125 and 250 mg/kg) ameliorated short-term and spatial memory functions. The mechanisms included: reducing elevated AChE, increasing decreased ChAT, and restoring reduced PSD-95 and BDNF levels .

Clinical Study Support: A multicenter clinical trial on 2,044 patients suffering from recent stroke receiving Alpha-GPC (1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months) confirmed the therapeutic role of Alpha-GPC on cognitive recovery based on four measurement scales, three of which reached statistical significance