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72432-10-1 Aniracetam Ro 13-5057 AMPA Receptor Positive Modulator
Brief Introduction
Brief Introduction
Aniracetam (development code: Ro 13-5057) is a pyrrolidinone-type cognition enhancer originally developed by Roche . As an important member of the racetam family, Aniracetam has demonstrated significant cognitive-enhancing effects in both preclinical and clinical studies, particularly showing therapeutic potential in the treatment of behavioral and psychological symptoms of dementia following stroke and in Alzheimer's disease . Compared to the classic nootropic Piracetam, Aniracetam exhibits higher potency and a broader range of target sites.
Key Scientific Value & Findings
Positive Modulation of AMPA Receptors: Aniracetam acts as a positive allosteric modulator of AMPA-sensitive glutamate receptors . It both increases the peak amplitude and reduces the rate of decay of the ion current generated by AMPA, thereby enhancing glutamatergic neurotransmission . In cultured neurons, Aniracetam enhances AMPA-stimulated calcium influx .
Dual Mechanism of Action: Research indicates that Aniracetam exerts a dual effect on glutamatergic transmission—modulation of NMDA receptor function at nanomolar concentrations and modulation of AMPA receptors at high micromolar concentrations . This concentration-dependent dual action makes it a uniquely valuable tool in neuroscience research.
Anti-Alzheimer's Disease Potential: A 2024 study published in the Journal of Alzheimer's Disease proposed the first evidence-based model for aniracetam reducing and preventing the accumulation of amyloid-β (Aβ) plaques . Aniracetam may prevent Aβ production and accumulation by increasing α-secretase activity through two distinct pathways: 1) increasing brain-derived neurotrophic factor (BDNF) expression; and 2) positively modulating metabotropic glutamate receptors .
Broad Neuropsychiatric Effects: Aniracetam has shown therapeutic potential in various rodent models of mental function impairment, including hypoattention, hypovigilance-arousal, impulsiveness, hyperactivity, fear, anxiety, and depression . These studies provide a basis for its application in research on attention-deficit/hyperactivity disorder, anxiety disorders, depression, posttraumatic stress disorder, and other conditions .
Modulation of Neurotransmitter Systems: Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms . Additionally, it promotes noradrenaline release in the hippocampus .
Our Supply & Service Advantages
Our Supply & Service Advantages
we are committed to providing global customers with comprehensive support ranging from products to services:
Stable Supply, Consistent Quality: Leveraging robust Chinese manufacturing resources, we ensure stable delivery of bulk orders with consistent quality across all batches.
Strong Price Competitiveness: Our factory-direct supply system eliminates intermediary costs, offering you highly competitive prices in the market.
Quality Assurance, Fully Traceable: We implement strict quality control systems and provide complete documentation, including Certificates of Analysis (CoA), heavy metal and microbiological test reports.
Flexible Packaging, Custom Services: We offer diverse packaging options (such as 1kg aluminum foil bags and 25kg fiber drums) and can meet customization needs including OEM and private label services.
Global Logistics, Efficient Delivery: Through close partnerships with internationally renowned logistics companies (DHL, FedEx) and major air/sea carriers, we ensure safe and rapid delivery to your destination.
Experienced Export Expertise: We focus on serving global distributors and manufacturers, with extensive international export experience that allows us to handle complex export procedures, making cooperation hassle-free.
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We provide COA (Certificate of Analysis) for each batch. Third-party testing is welcome