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51352-87-5 PRL-8-53 Nootropic Compound Learning and Memory Enhancer
Brief Introduction
Brief Introduction
PRL-8-53 is an experimental compound which many believe to be one of the most effective memory boosters available.It is a nootropic research chemical derived from benzoic acid and phenylmethylamine with memory-enhancing effects, used in neuroscience research related to memory enhancement and protection against memory impairment.
in medicine used in neuroscience research related to memory enhancement and protection against memory impairment.
in medicine used in neuroscience research related to memory enhancement and protection against memory impairment.
PRL-8-53 (chemical name: Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate hydrochloride) is a phenethylamine derivative classified as a psychotropic agent and nootropic . This compound has garnered continued research interest due to its significant memory retention-enhancing effects demonstrated in a human double-blind clinical trial published in 1978 . PRL-8-53's structure and mechanism differ from classic racetam compounds, offering a unique molecular tool for cognitive function research.
Key Scientific Value & Findings
Human Clinical Study Evidence: A double-blind clinical trial published in the journal Psychopharmacology in 1978 investigated the effects of PRL-8-53 on learning and retention of verbal information in human subjects . Key findings include:
Significant Memory Retention Enhancement: PRL-8-53 produced a statistically significant positive effect on the retention of verbal information (most P values better than 0.01, some better than 0.001)
Mild Improvement in Acquisition: The drug caused slight improvement in learning acquisition
No Motor/Sensory Interference: No significant changes were found for either visual reaction time or motor control after drug treatment compared with placebo values
Phenethylamine Derivative Structure: PRL-8-53 is a derivative of 2-phenylethylamine, a structural scaffold with some relation to endogenous neurotransmitters such as dopamine and norepinephrine, though its precise mechanism of action has not been fully elucidated . Its structure is C₁₈H₂₂ClNO₂ with a molecular weight of 319.83 g/mol .
Oral Activity: PRL-8-53 has been confirmed as an orally active psychotropic agent, with the original human study employing oral administration .
Historical Literature Position: A 1983 Chinese-language publication listed PRL-8-53 alongside compounds like methylphenidate as memory-enhancing agents, indicating its place in nootropic research history
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Our Supply & Service Advantages
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