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5-Amino-1-Methylquinolinium Iodide CAS 42464-96-0 - High Purity Suppliers from China Factory
Brief Introduction
NNMTi (CAS 42464-96-0) is a nicotinamide N-methyltransferase (NNMT) inhibitor that promotes myoblast differentiation. NNMT is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics.
- ● NNMTi treatment combined with lean diet substitution accelerated improved body weight fat loss
- ● Increased whole-body lean mass to body weight ratio
- ● Reduced liver epididymal white adipose tissue weights
- ● Decreased liver adiposity and improved hepatic steatosis, relative to a lean diet substitution alone
NNMTi is an enzyme overexpressed during skeletal muscle aging and is associated with the repair of damage to the NAD+ pathway, dysregulation of sirtuin1 activity, and increased senescence of muscle stem cells.
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Frequently Asked Questions
Q
What is NNMTi (CAS 42464-96-0) and what is its primary function?
NNMTi (CAS 42464-96-0) is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme responsible for the N-methylation of nicotinamide and other xenobiotics. Its primary function includes promoting myoblast differentiation and modulating metabolic pathways associated with obesity and muscle aging.
Q
How does NNMTi contribute to body weight and fat loss?
When combined with lean diet substitution, NNMTi treatment has been shown to accelerate body weight fat loss, increase whole-body lean mass to body weight ratio, reduce liver and epididymal white adipose tissue weights, and improve hepatic steatosis — effects that are more pronounced than lean diet substitution alone.
Q
What is the role of NNMT in skeletal muscle aging?
NNMT is overexpressed during skeletal muscle aging. Its overexpression is associated with damage to the NAD+ pathway, dysregulation of sirtuin1 (SIRT1) activity, and increased senescence of muscle stem cells, all of which contribute to age-related muscle decline. Inhibiting NNMT with NNMTi may help mitigate these effects.
Q
What is the connection between NNMTi and the NAD+ pathway?
NNMT consumes S-adenosylmethionine (SAM) to methylate nicotinamide, which can reduce NAD+ biosynthesis. By inhibiting NNMT, NNMTi helps restore NAD+ levels, supporting cellular energy metabolism, sirtuin activity, and overall metabolic health — particularly relevant in aging muscle tissue.
Q
Is NNMTi suitable for research use only, or does it have clinical applications?
NNMTi is currently primarily used as a research compound to study NNMT biology, metabolic disorders, muscle aging, and obesity-related conditions. Its potential clinical applications are an active area of investigation, and ongoing studies continue to explore its therapeutic relevance in metabolic disease and muscle regeneration.
Q
How can I order NNMTi, and what quantities are available?
NNMTi is available in various quantities to support both small-scale laboratory research and larger commercial applications. Please contact our team directly for pricing, availability, custom synthesis options, and bulk order inquiries. Our experts are ready to assist with your specific requirements.