01
157115-85-0 Noopept GVS-111 Nootropic Peptide Omberacetam
Brief Introduction
Brief Introduction
Noopept is a well-known nootropic that is often suggested as a first nootropic.Noopept is over 500 times more potentthan Piracetam.Like piracetam,it is capable of enhancing memory,learning,andfocus. Noopept is also a powerful antioxidant that prevents neurological disorders andhelps the brain grow.Because of this, it is thought to improve long-term memory. The human studies have shown promising results, with potential application in the treatment of Alzheimer's disease.
Noopept (development codes: GVS-111, SGS-111; INN: Omberacetam) is a proline-containing synthetic dipeptide developed by the Russian Academy of Sciences using an original approach based on the imitation of a nonpeptide nootrope (piracetam) structure by means of short-peptide design . It is approved in Russia as a cognition enhancer and differs structurally from classic racetams, belonging to the dipeptide class of nootropics with dual nootropic and neuroprotective effects.
Key Scientific Value & Findings
Ultra-High Potency - 1000-fold Stronger than Piracetam: Experimental studies show that Noopept exceeds piracetam by 1000 times in effective dose level . In contrast to piracetam facilitating only the early stages of the memory process, Noopept positively influences the memory consolidation and retrieval steps as well . Additionally, Noopept produces an additional selective anxiolytic action .
Unique Neuroprotective Mechanism: Noopept demonstrates pronounced neuroprotective effects confirmed both in vivo (in various forms of brain ischemia) and in vitro (on various neuronal models) . Its action is based on:
Antioxidant effect
Anti-inflammatory action
Ability to inhibit neurotoxicity of excess calcium and glutamate
Improvement of blood rheology
α7 Nicotinic Acetylcholine Receptor-Mediated Modulation: A 2022 study found that Noopept (5 µM) increases action potential firing frequency recorded from GABAergic interneurons in the stratum radiatum of hippocampal CA1 region. This effect was almost completely abolished by α7 nAChR-selective antagonists (α-bungarotoxin and methyllycaconitine), indicating that α7 nAChRs are an important site of action of Noopept .
HIF-1 Signaling Pathway Activation: Research indicates that Noopept is a moderate activator of the HIF-1 signaling pathway, acting through HIF-1 stabilization, likely by inducing HIF-1α transcription and translation, resulting in increased HIF-dependent gene expression. This mechanism may contribute to its neurotropic activity .
Alzheimer's Disease Research Potential:
In an Alzheimer's disease model induced by β-amyloid (25-35) injection into Meynert basal nuclei, Noopept (0.5 mg/kg, preventive intraperitoneal injections) completely prevented mnestic disorders
Even when treatment was started 15 days after injury (when neurodegenerative changes were still acutely pronounced), Noopept exhibited a significant normalizing effect
Mechanisms include: choline-positive effect, multicomponent neuroprotective effect, stimulation of antibody production to β-amyloid
Oral Bioavailability Advantage: It was established for the first time that the activity of Noopept is retained both upon parenteral introduction and upon peroral administration, which is a principal advantage of this proline-containing dipeptide over other, more complex peptides . This property provided a basis for the development of oral formulations.
Our Supply & Service Advantages
Our Supply & Service Advantages
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Stable Supply, Consistent Quality: Leveraging robust Chinese manufacturing resources, we ensure stable delivery of bulk orders with consistent quality across all batches.
Strong Price Competitiveness: Our factory-direct supply system eliminates intermediary costs, offering you highly competitive prices in the market.
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